Navigating Medical Office Space in NYC: Prime Leasing Opportunities

Securing the ideal medical office space in Manhattan presents a unique set of hurdles and opportunities. While many landlords harbor reservations about the increased foot traffic associated with medical practices and the complexities of specialized buildouts involving extensive plumbing, detailed millwork, and additional restrooms, the demand for accessible healthcare facilities remains strong. These specialized construction requirements often lead landlords to hesitate in absorbing the added expenses. Furthermore, while ground-floor locations in residential buildings can be attractive, they often command premium prices, and owners may have limited capacity to contribute to the necessary medical infrastructure.

➡️ For a comprehensive guide on the unique needs and considerations for medical tenants, see Medical Office Space in NYC: The Ultimate Guide to Finding Space.

Despite these complexities, several commercial properties in Manhattan actively welcome medical tenants and offer attractive concession packages to assist with the build-out process. The following list highlights prime leasing opportunities in buildings that cater to or readily accept medical use, providing a valuable starting point for your search:

1. 210 East 86th Street (Between Second & Third Avenue)           
   Available Space: Multiple full and partial floors
   Size: 3,000 sq ft – 30,000 sq ft
   Comments: This rare Upper East Side medical building offers flexibility to house multiple medical divisions. Floor plates range from 9,000 sq ft to 14,000 sq ft and can be easily divided to suit various needs. Benefit from excellent transportation access. Current tenants include Weill Cornell and NY Cancer & Blood Specialists
   
   
   
   
   

2. 110 East 60th Street (Between Lexington & Park Avenue)
   Available Space: Multiple units ranging from 2,000 sq ft to 12,300 sq ft
   Comments: This fully renovated medical building has undergone $20 million in recent upgrades. Enjoy ideal access to both the Upper East Side and Midtown.
   
   
   
   
   
   

3. 115 East 57th Street/The Galleria (Between Lexington & Park Avenue)
   Available Space: Multiple full and partial floors
   Size: 2,000 – 6,000 – 9,000 – 16,000 sq ft
   Comments: This is a dedicated medical building offering ideal access to both the Upper East Side and Midtown.
   
   
   

4. 200 West 57th Street (Seventh Avenue)
   Available Space: Medical offices ranging from 800 sq ft to 5,000 sq ft. High-end, pre-built spaces from 800 sq ft to 5,000 sq ft are available, offering above-standard installations, private restrooms, a wet pantry, and tenant-controlled HVAC. Benefit from direct subway access and proximity to both the Upper West Side and Midtown.
   
   
   

5. 20 East 46th Street (Between Madison & Fifth)
   Available Space: Medical offices ranging from 1,000 – 6,000 sq ft.
   Comments: Enjoy great proximity to Grand Central Terminal and the Midtown office community.
   
   
   
   
   
   

6. 145 East 32nd Street
   Available Space: Entire 11th & 12th Floors
   Size: 5,500 sq ft each
   Comments: Features existing medical buildouts. The spaces can potentially be divided. Current tenants include NYU/Langone, Manhattan Internal Medicine, & Advanced Urology Center. Benefit from a great Murray Hill location and proximately to Langone.
   
   
   
   
   

7. 362 Fifth Avenue (34th Street)
   Available Space: Small suites and full floors ranging from 800 sq ft to 5,800 sq ft
   Comments: Ideally located across from the iconic Empire State Building.
   
   
   
   
   
   

8. 24-32 Union Square East
   Available Space: Full floors of 13,559 sq ft
   Comments: This building overlooks Union Square Park and offers an ideal location next to all major subway lines.
   
   
   
   
   
   

9. 275 Seventh Avenue (25th & 26th Street)
   Available Space: Multiple sizes ranging from 5,000 sq ft to 20,000 sq ft
   Comments: Enjoy an ideal Chelsea location. Current tenants include NYU Langone.
   
   
   
   
   
   
   
   
   

10. 380 Second Avenue (22nd Street)
    Available Space: 10,000 – 20,000 sq ft
    Comments: This is a dedicated medical building. Current tenants include NYU Langone, Hospital for Joint Disease, East Side Endoscopy & Gramercy Surgical Center.
    
    
    
    
    
    
    

11. 233 Broadway/The Woolworth Building (Between Barclay Street & Park Place)
    Available Space: Spaces ranging from 1,000 – 30,000 sq ft.
    Comments: This is an iconic downtown property. Close to transportation and the Downtown office and residential market.
    
    
    
    
    
    

12. 156 William Street
    Available Space: Multiple spaces ranging from 10,000 – 15,000 – 20,000 sq ft
    Asking Price: $58 per sq ft
    Comments: This is a dedicated medical building. Current tenants include Weill Cornell and Liberty Endoscopy.
    
    
    

➡️ For insights on the resilience and investment trends in NYC’s medical office market, read Medical Offices a Hidden Healthy Gem in New York’s Office Market.

➡️ For tips on finding the right property, avoiding hidden costs, and negotiating favorable terms, see Medical Space for Lease and Rent in Manhattan and NYC.

Navigating the medical real estate market in NYC requires expertise and a keen understanding of the specific needs of medical practices. Contact us today to explore these and other suitable properties and to learn how we can assist you in finding the perfect space for your medical office.

Paul Walker
212-984-7117
Paul.Walker@cbre.com